Here is one example of a set of video scenarios that depicts an appropriate response, versus an inappropriate response to a social interruption during work. 

This is the right way to respond when you don’t have time to make small talk. Matt looks towards his co–worker and uses a polite tone of voice. He tells his co–worker that he cannot talk right now, but he would like to chat with him during lunch.
This is the wrong way to respond when you don’t have time to make small talk. Matt does not look towards his co–worker. He uses a rude hand signal (pointing his finger). Matt uses a rude tone of voice, and he only says, "Not now." This will probably make his co–worker avoid him in the future. 
Pleasant Voice

Listen to this person’s tone of voice. This is an example of someone with a pleasant and polite tone of voice. He keeps his voice upbeat and asks in a polite way to finish the task he is currently working on.

Irritated Voice

Listen to this person’s tone of voice. This is an example of someone with an irritated and rude tone of voice. He sounds very annoyed as he is asking to finish the task he is working on. This tone of voice might make people think that this person is not nice or friendly.